Splice and sequence
نویسندگان
چکیده
منابع مشابه
Modelling splice sites with locality-sensitive sequence features
The splice sites are essential for pre-mRNA maturation and crucial for Splice Site Modelling (SSM); however, there are gaps between the splicing signals and the computationally identified sequence features. In this paper, the Locality Sensitive Features (LSFs) are proposed to reduce the gaps by homogenising their contexts. Under the skewness-kurtosis based statistics and data analysis, SSM attr...
متن کاملMutation in an intervening sequence splice junction in man.
The alpha 2-globin gene of an individual with alpha-thalassemia associated with the absence of alpha 2 mRNA was cloned in bacteriophage. This mutant globin gene was normally active in transcription in vitro. The DNA sequence of the gene, however, revealed a pentanucleotide deletion within the 5' splice junction of the first intervening sequence. Following the G of the invariant G-T dinucleotide...
متن کاملDNA Encoding for Splice Site Prediction in Large DNA Sequence
Splice site prediction in the pre-mRNA is a very important task for understanding gene structure and its function. To predict splice sites, SVM (support vector machine) based classification technique is frequently used because of its classification accuracy. High classification accuracy of SVM largely depends on DNA encoding method for feature extraction of DNA sequences. However, existing enco...
متن کاملSplice Graphs and their Vertex-Degree-Based Invariants
Let G_1 and G_2 be simple connected graphs with disjoint vertex sets V(G_1) and V(G_2), respectively. For given vertices a_1in V(G_1) and a_2in V(G_2), a splice of G_1 and G_2 by vertices a_1 and a_2 is defined by identifying the vertices a_1 and a_2 in the union of G_1 and G_2. In this paper, we present exact formulas for computing some vertex-degree-based graph invariants of splice of graphs.
متن کاملThe Baboon Kidney Transcriptome: Analysis of Transcript Sequence, Splice Variants, and Abundance
The baboon is an invaluable model for the study of human health and disease, including many complex diseases of the kidney. Although scientists have made great progress in developing this animal as a model for numerous areas of biomedical research, genomic resources for the baboon, such as a quality annotated genome, are still lacking. To this end, we characterized the baboon kidney transcripto...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Methods
سال: 2015
ISSN: 1548-7091,1548-7105
DOI: 10.1038/nmeth.3427